Title:Microwave-assisted Synthesis of Novel Pyrazole Derivatives and their Biological Evaluation as Anti-Bacterial Agents
VOLUME: 24 ISSUE: 5
Author(s):Hadis Khodadad, Farhad Hatamjafari*, Khalil Pourshamsian* and Babak Sadeghi
Affiliation:Department of Chemistry, Faculty of Science, Islamic Azad University, Tonekabon Branch, Tonekabon, Department of Chemistry, Faculty of Science, Islamic Azad University, Tonekabon Branch, Tonekabon, Department of Chemistry, Faculty of Science, Islamic Azad University, Tonekabon Branch, Tonekabon, Department of Chemistry, Faculty of Science, Islamic Azad University, Tonekabon Branch, Tonekabon
Keywords:Pyrazole; Chalcone; Microwave Assisted; Antibacterial; FT-IR; 1H NMR and 13C NMR.
Abstract:Aim and Objective: Microwave-assisted condensation of acetophenone 1 and aromatic
aldehydes 2 gave chalcone analogs 3, which were cyclized to pyrazole derivatives 6a-f via the
reaction with hydrazine hydrate and oxalic acid in the presence of the catalytic amount of acetic
acid in ethanol.
Materials and Methods: The structural features of the synthesized compounds were characterized
by melting point, FT-IR, 1H, 13C NMR and elemental analysis.
Results: The antibacterial activities of the synthesized pyrazoles were evaluated against three
gram-positive bacteria, such as Enterococcus durans, Staphylococcus aureus, Bacillus subtilis and
two gram-negative bacteria such as Escherichia coli and Salmonella typhimurium.
Conclusion: All the synthesized pyrazoles showed relatively high antibacterial activity against S.
aureus strain, and none of them demonstrated antibacterial activity against E. coli.
