Aim and Objective: Microwave-assisted condensation of acetophenone 1 and aromatic
aldehydes 2 gave chalcone analogs 3, which were cyclized to pyrazole derivatives 6a-f via the
reaction with hydrazine hydrate and oxalic acid in the presence of the catalytic amount of acetic
acid in ethanol.
Materials and Methods: The structural features of the synthesized compounds were characterized
by melting point, FT-IR, 1H, 13C NMR and elemental analysis.
Results: The antibacterial activities of the synthesized pyrazoles were evaluated against three
gram-positive bacteria, such as Enterococcus durans, Staphylococcus aureus, Bacillus subtilis and
two gram-negative bacteria such as Escherichia coli and Salmonella typhimurium.
Conclusion: All the synthesized pyrazoles showed relatively high antibacterial activity against S.
aureus strain, and none of them demonstrated antibacterial activity against E. coli.