Treatment of Hepatitis C Cirrhotic Patients With Directly Acting Antivirals: A Multicenter Study

Author(s): Asem Ahmed Elfert, Sherief Abd-Elsalam*, Lobna Abo-Ali, Taher Eldemerdash, Sabry Abou-Saif, Hala Mostafa Elsabagh, Abla Ebeid, Rehab Badawi

Journal Name: Infectious Disorders - Drug Targets
Formerly Current Drug Targets - Infectious Disorders

Volume 21 , Issue 5 , 2021


Article ID: e270421186971
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Abstract:

Background: With the introduction of sofosbuvir-based regimens, high cure rates and decreased duration has been achieved. Several studies showed variances in SVR rates between different genotypes, with lower rates of SVR among cirrhotic patients. The aim of our study was to assess the safety and effectiveness of sofosbuvir-based antiviral regimens for the treatment of HCVinfected Egyptian cirrhotic patients.

Methods: This was a retrospective, observational, and comparative study. A total of nine hundred and forty-six cirrhotic patients with chronic HCV genotype 4 infection, who were eligible for direct acting drugs (DAAs) therapy, were enrolled. The primary outcome measures were the number of patients with successful eradication of the virus evidenced by SVR at 12 weeks after discontinuation of therapy (SVR12), and the secondary outcome measures were the incidence of adverse effects associated with the tested HCV therapy.

Results: Among the 946 patients enrolled in the study, 527 patients (55.7%) were males and 419 patients (44.3%) were females with a mean age of 54.00±8.88 years. 20.2% were diabetics and 19.1% were hypertensive. Patients were classified according to Child-Pugh classifications; 818 patients (86.46%) were Child-Pugh class A cirrhosis, while 28 patients (13.53%) were Child-Pugh class B cirrhosis. The SVR12 rate was 96.93% (917 /946). Treatment response in the Child-Pugh class A cirrhosis was 794 (97%) after 12 weeks, while treatment response in the Child-Pugh class B cirrhosis was 123 (96%). Mild side effects were observed in 76 patients.

Conclusions: Sofosbuvir based regimens were effective and safe in the treatment of cirrhotic patients with chronic hepatitis C genotype 4.

Keywords: Hepatitis C virus, cirrhosis, genotype 4, viral hepatitis, sofosbuvir, Egypt.

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Article Details

VOLUME: 21
ISSUE: 5
Year: 2021
Published on: 19 October, 2020
Article ID: e270421186971
Pages: 7
DOI: 10.2174/1871526520666201019122205
Price: $65

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