Application of Hydrogen in Ophthalmology

Author(s): Hiroshi Takahashi*

Journal Name: Current Pharmaceutical Design

Volume 27 , Issue 5 , 2021


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Abstract:

This report reviews studies on the use of H2 in the ophthalmological field. In retinal diseases, particularly in a retinal ischemia-reperfusion injury, effects of H2 are remarkable in reducing retinal tissue damage. H2 treatment of corneal damage caused by alkali or UVB suppressed scar formation. The most unique application of H2 in the ophthalmological field appears to be its use in phacoemulsification cataract surgery. Ultrasound oscillation produces ·OH through the cavitation phenomenon in the anterior chamber of the eye, which induces oxidative insults in the corneal endothelium. Phacoemulsification using H2 dissolved in the irrigation solution significantly suppressed the corneal endothelial damage. The effect of H2 was direct and clear, as H2 instantly scavenges ·OH produced by ultrasound oscillation in the anterior chamber, thereby suppressing oxidative insults during the phacoemulsification procedure.

Keywords: Ophthalmology, retinal ischemia-reperfusion injury, retinal disease, corneal injury, phacoemulsification, corneal endothelium, cataract surgery.

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Article Details

VOLUME: 27
ISSUE: 5
Year: 2021
Published on: 13 March, 2021
Page: [592 - 594]
Pages: 3
DOI: 10.2174/1381612826666201019103446
Price: $65

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