Background: Osteosarcoma is the most common type of primary bone tumor in children
and adolescents, which is associated with rapid progression and poor prognosis. Multimodal
therapy is the most common approach utilized for osteosarcoma management, such as the application
of chemotherapy in combination with surgery or radiation therapy. Cisplatin is one of the predominantly
used chemotherapeutic agents for osteosarcoma. Optimally, it is employed in combination
with other chemotherapeutic drugs along with surgery or radiation therapy. Despite the availability
of numerous treatment approaches, the patient survival rate has not definitively improved
over the past three decades.
Methods: We have summarized all findings regarding the combination of cisplatin with other chemotherapeutic
agents as well as with phytochemical compounds.
Results: A combination of cisplatin with a phytochemical compound synergistically enhances the
killing effect of cisplatin on osteosarcoma cells with fewer side effects compared to combination
with other chemotherapeutic agents.
Conclusion: Conclusively, a combination of cisplatin with selected chemotherapeutic drugs has
been shown to be effective. However, the unchanged survival rate has posed an urge to search for a
new combination regimen. As a collaborative effort to substantiate the therapeutic efficacy, the
combination with phytochemical compounds shows a promising response both in vitro as well as
in the preclinical study.