Background: COVID-19 has been declared as a pandemic recently and has caused many
deaths worldwide. Till date, no effective drug or vaccine is available against SARS-CoV-2. There is an
urgent need to find effective alternative preventive and treatment strategies to deal with the SARS-CoV-
Objective: This communication proposes a new potential drug combination (repurposed) for prophylaxis
and treatment of SARS-CoV-2.
Methods and Materials: We performed a brief review of literature on a combination of Hydroxychloroquine,
Melatonin and Mercaptopurine for prophylaxis and treatment of Novel COVID-19 infection and
also assessed their possible mechanism of action against SARS-CoV-2.
Observation: Proposed combination seems to be safe, and the target is unlikely to develop resistance to
Conclusion: This scientific review proposes potential candidate repurposed drugs and potential drug
combinations targeting 2019-nCoV/SARS-CoV-2.