Title:C-Myc Signaling Pathway in Treatment and Prevention of Brain Tumors
VOLUME: 21 ISSUE: 1
Author(s):Milad Ashrafizadeh, Ali Zarabi, Kiavash Hushmandi, Ebrahim Rahmani Moghadam, Farid Hashemi, Salman Daneshi, Fardin Hashemi, Shima Tavakol, Reza Mohammadinejad, Masoud Najafi*, Namrata Dudha and Manoj Garg*
Affiliation:Faculty of Engineering and Natural Sciences, Sabanci University, Orta Mahalle, Universite Caddesi No. 27, Orhanli, Tuzla, 34956 Istanbul, Sabanci University Nanotechnology Research and Application Center (SUNUM), Tuzla, 34956, Istanbul, Department of Food Hygiene and Quality Control, Division of Epidemiology & Zoonoses, Faculty of Veterinary Medicine, University of Tehran, Tehran, Department of Anatomical sciences, School of Medicine, Student Research Committee, Shiraz University of Medical Sciences, Shiraz, DVM. Graduated, Young Researcher and Elite Club, Kazerun Branch, Islamic Azad University, Kazeroon, Department of Public Health, School of Health, Jiroft University of Medical Sciences, Jiroft, Student Research Committee, Department of physiotherapy, Faculty of rehabilitation, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran 1449614535, Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman 7619813159, Medical Technology Research Center, Institute of Health Technology, Kermanshah University of Medical Sciences, Kermanshah, Department of Biotechnology and Microbiology, School of Sciences, Noida International University, Gautam Budh Nagar, Uttar Pradesh, Amity of Molecular Medicine and Stem cell Research (AIMMSCR), Amity University Uttar Pradesh, Noida-201313
Keywords:Brain tumor, c-Myc, signaling pathway, glioma, glioblastoma, medulloblastoma, astrocytoma.
Abstract:Brain tumors are responsible for high morbidity and mortality worldwide. Several factors
such as the presence of blood-brain barrier (BBB), sensitive location in the brain, and unique
biological features challenge the treatment of brain tumors. The conventional drugs are no longer
effective in the treatment of brain tumors, and scientists are trying to find novel therapeutics for
brain tumors. In this way, identification of molecular pathways can facilitate finding an effective
treatment. c-Myc is an oncogene signaling pathway capable of regulation of biological processes
such as apoptotic cell death, proliferation, survival, differentiation, and so on. These pleiotropic effects
of c-Myc have resulted in much fascination with its role in different cancers, particularly
brain tumors. In the present review, we aim to demonstrate the upstream and down-stream mediators
of c-Myc in brain tumors such as glioma, glioblastoma, astrocytoma, and medulloblastoma.
The capacity of c-Myc as a prognostic factor in brain tumors will be investigated. Our goal is to
define an axis in which the c-Myc signaling pathway plays a crucial role and to provide direction
for therapeutic targeting in these signaling networks in brain tumors.
