Brain tumors are responsible for high morbidity and mortality worldwide. Several factors
such as the presence of blood-brain barrier (BBB), sensitive location in the brain, and unique
biological features challenge the treatment of brain tumors. The conventional drugs are no longer
effective in the treatment of brain tumors, and scientists are trying to find novel therapeutics for
brain tumors. In this way, identification of molecular pathways can facilitate finding an effective
treatment. c-Myc is an oncogene signaling pathway capable of regulation of biological processes
such as apoptotic cell death, proliferation, survival, differentiation, and so on. These pleiotropic effects
of c-Myc have resulted in much fascination with its role in different cancers, particularly
brain tumors. In the present review, we aim to demonstrate the upstream and down-stream mediators
of c-Myc in brain tumors such as glioma, glioblastoma, astrocytoma, and medulloblastoma.
The capacity of c-Myc as a prognostic factor in brain tumors will be investigated. Our goal is to
define an axis in which the c-Myc signaling pathway plays a crucial role and to provide direction
for therapeutic targeting in these signaling networks in brain tumors.