Title:JAK2-mediated Intracellular Signaling
VOLUME: 21 ISSUE: 5
Author(s):Mentor Sopjani*, Rifat Morina, Valdet Uka, Nguyen Thi Xuan and Miribane Dërmaku-Sopjani*
Affiliation:Faculty of Medicine, University of Prishtina, 10 000, Prishtinë, Faculty of Education, University of Prizren, 20 000, Prizren, Faculty of Medicine, University of Prishtina, 10 000, Prishtinë, Institute of Genome Research, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Cau Giay, Hanoi, Faculty of Natural Sciences and Mathematics, University of Prishtina, 10 000, Prishtinë
Keywords:Jak2, STAT, protein kinases, hormones, intracellular signaling.
Abstract:Janus kinase-2 (JAK2) is a non-receptor tyrosine kinase that serves key roles
as the intracellular signaling effector of the cytokine receptor, such as mediating effects
of leptin, erythropoietin, interferon, and growth hormone. A lot of molecular underlying
mechanisms of JAK2 participation are known, however, additional signaling
mechanisms of its activation, regulation, and pleiotropic signaling roles are still being
explored. Here, we review the current knowledge of JAK2-mediated cellular signaling at
the molecular level. In the beginning, we will focus on the recent advances in JAK2
activation and regulation. A part of our review focuses on the JAK2 involvement in
various diseases/conditions. Recent advances highlight the molecular regulatory
mechanisms utilized by the JAK2 signaling, thus, enabling to consider alternative
therapeutic strategies to treat various diseases/conditions mediated by JAK2 by using it
as a therapeutic target.
