Background: The typical imaging finding of MM is bone destruction in the form of diffuse
patchy osteolytic lesions or punctate destruction. However, it is difficult to accurately determine
the fine structure of bone affected by MM with these techniques due to low specificity and
Introduction: This study aimed to investigate the microscopic anatomical morphology and analyze
the microstructure changes of trabeculae affected by multiple myeloma (MM) based on micro-CT.
Methods: MM-affected and normal trabecular bone samples were imaged by micro-CT to obtain
bone structure parameters to assess statistical differences between them and evaluate the degree of
microstructural damage of MM-affected trabeculae.
Results: Micro CT images clearly showed the microstructure of MM-affected trabeculae. The degree
of trabecular osteoporosis varied with the severity of MM. There were significant differences
in the structural parameters between MM-affected and normal trabeculae (P < 0.05).
Conclusion: Micro-CT clearly reveals the microstructure of MM-affected trabeculae. The obtained
bone structure data will help to determine the degree of bone damage caused by MM and assess the
Keywords: Multiple myeloma, trabeculae, micro-CT, microarchitecture, pathological osseous tissue, X-ray.
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