The Evaluation of the Multiple Myeloma Pathological Osseous Tissue of Microarchitecture

Author(s): Lianxiang Chen, Xing Wang, Shaojie Zhang, Wei Wang, Baoke Su, Xuebin Xu, Dongchen Lv, Wentao Liu, Xiaohe Li*, Zhijun Li*

Journal Name: Current Medical Imaging
Formerly: Current Medical Imaging Reviews

Volume 17 , Issue 4 , 2021


Become EABM
Become Reviewer
Call for Editor

Graphical Abstract:


Abstract:

Background: The typical imaging finding of MM is bone destruction in the form of diffuse patchy osteolytic lesions or punctate destruction. However, it is difficult to accurately determine the fine structure of bone affected by MM with these techniques due to low specificity and sensitivity.

Introduction: This study aimed to investigate the microscopic anatomical morphology and analyze the microstructure changes of trabeculae affected by multiple myeloma (MM) based on micro-CT.

Methods: MM-affected and normal trabecular bone samples were imaged by micro-CT to obtain bone structure parameters to assess statistical differences between them and evaluate the degree of microstructural damage of MM-affected trabeculae.

Results: Micro CT images clearly showed the microstructure of MM-affected trabeculae. The degree of trabecular osteoporosis varied with the severity of MM. There were significant differences in the structural parameters between MM-affected and normal trabeculae (P < 0.05).

Conclusion: Micro-CT clearly reveals the microstructure of MM-affected trabeculae. The obtained bone structure data will help to determine the degree of bone damage caused by MM and assess the efficacy.

Keywords: Multiple myeloma, trabeculae, micro-CT, microarchitecture, pathological osseous tissue, X-ray.

[1]
Sergentanis TN, Kastritis E, Terpos E, Dimopoulos MA, Psaltopoulou T. Cytogeneticsand survival of multiple myeloma: isolated and combined effects. Clin Lymphoma Myeloma Leuk 2016; 16(6): 335-40.
[http://dx.doi.org/10.1016/j.clml.2016.03.006] [PMID: 27101987]
[2]
Jian Y, Chen X, Zhou H, et al. Prognostic impact of cytogenetic abnormalitiesin multiple myeloma: a retrospective analysis of 229 patients. Medicine (Baltimore) 2016; 95(19): e3521.
[http://dx.doi.org/10.1097/MD.0000000000003521] [PMID: 27175647]
[3]
Hutchinson EF, Farella M, Hoffman J, Kramer B. Variations in bone density across the body of the immature human mandible. J Anat 2017; 230(5): 679-88.
[http://dx.doi.org/10.1111/joa.12591] [PMID: 28256069]
[4]
Yan H, Zheng G, Qu J, et al. Identification of key candidate genes and pathways in multiple myeloma by integrated bioinformatics analysis. J Cell Physiol 2019; 234(12): 23785-97.
[http://dx.doi.org/10.1002/jcp.28947] [PMID: 31215027]
[5]
Weil C, Gelerstein S, Sharman Moser S, et al. Real-world epidemiology, treatment patterns and survival of multiple myeloma patients in a large nationwide health plan. Leuk Res 2019; 85(85): 106219.
[http://dx.doi.org/10.1016/j.leukres.2019.106219] [PMID: 31473468]
[6]
Wang Y, Li Q, Xing S, Zhang H, Li D. Clinical characteristics and prognosis of MAF deletion in chinese patients with multiple myeloma. Clin Lymphoma Myeloma Leuk 2019; 19(9): e545-50.
[http://dx.doi.org/10.1016/j.clml.2019.05.016] [PMID: 31262667]
[7]
Gooding S, Olechnowicz SWZ, Morris EV, et al. Transcriptomic profiling of the myeloma bone-lining niche reveals BMP signalling inhibition to improve bone disease. Nat Commun 2019; 10(1): 4533.
[http://dx.doi.org/10.1038/s41467-019-12296-1] [PMID: 31586071]
[8]
Wyatt S, De Risio L, Driver C, et al. Neurological signs and MRI findings in 12 dogs with multiple myeloma. Vet Radiol Ultrasound 2019; 60(4): 409-415..
[9]
Chng WJ, Dispenzieri A, Chim CS, et al. International myeloma working group. IMWG consensus on risk stratification in multiple myeloma. Leukemia 2014; 28(2): 269-77.
[http://dx.doi.org/10.1038/leu.2013.247] [PMID: 23974982]
[10]
Kosmala A, Bley T, Petritsch B. Imaging of multiple myeloma. Rofo 2019; 191(9): 805-816..
[11]
Mosebach J, Thierjung H, Schlemmer HP, Delorme S. Multiple myeloma guidelines and their recent updates: Implications for imaging. RoFo Fortschr Geb Rontgenstr Nuklearmed 2019; 191(11): 998-1009.
[http://dx.doi.org/10.1055/a-0897-3966] [PMID: 31137045]
[12]
Sergentanis TN, Kastritis E, Terpos E, Dimopoulos MA, Psaltopoulou T. Cytogeneticsand survival of multiple myeloma: isolated and combined effects. Clin Lymphoma Myeloma Leuk 2016; 16(6): 335-40.
[http://dx.doi.org/10.1016/j.clml.2016.03.006] [PMID: 27101987]
[13]
Van Wier S, Braggio E, Baker A, et al. Hypodiploid multiple myeloma is characterized by more aggressive molecular markers than non-hyperdiploid multiple myeloma. Haematologica 2013; 98(10): 1586-92.
[http://dx.doi.org/10.3324/haematol.2012.081083] [PMID: 23716545]
[14]
Fallon EM, Nazarian A, Nehra D, et al. The effect of docosahexaenoic acid on bone microstructure in young mice and bone fracture in neonates. J Surg Res 2014; 191(1): 148-55.
[http://dx.doi.org/10.1016/j.jss.2014.04.005] [PMID: 24793452]
[15]
Kauppinen S, Karhula SS, Thevenot J, et al. 3D morphometric analysis of calcified cartilage properties using micro-computed tomography. Osteoarthritis Cartilage 2019; 27(1): 172-80.
[http://dx.doi.org/10.1016/j.joca.2018.09.009] [PMID: 30287395]
[16]
Cunningham CA, Black SM. The vascular collar of the ilium: three-dimensional evaluation of the dominant nutrient foramen. Clin Anat 2013; 26(4): 502-8.
[http://dx.doi.org/10.1002/ca.22213] [PMID: 23335258]


open access plus

Rights & PermissionsPrintExport Cite as

Article Details

VOLUME: 17
ISSUE: 4
Year: 2021
Published on: 15 October, 2020
Page: [513 - 516]
Pages: 4
DOI: 10.2174/1573405616666201015144015

Article Metrics

PDF: 36
HTML: 2