Multicomponent Reactions of Indoles with 1-Amino-5-aroyl-4-aryl-1HPyrimidin- 2-ones / -thiones: One-pot Three Component Synthesis of Novel Gramine Analogues

Author(s): Hava Aydın, Elif Korkusuz, İsmail Yıldırım*

Journal Name: Letters in Organic Chemistry

Volume 18 , Issue 9 , 2021

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Graphical Abstract:


A one-pot three component synthesis of a series of new gramine derivatives was designed and achieved via reactions of indole or N-methylindole with aromatic aldehyde and heteroaryl amines at 80-110 °C for 10-24 hours in an oven under solvent- and catalyst-free conditions providing an efficient, convenient and green method for the syntheses of a series of indol-3-yl- and N-methylindol-3-yl-1-aminopyrimidin-2-ones/thiones. So, fourteen novel gramine derivatives were conveniently synthesized and characterized by elemental analyses, FT IR, 1H and 13C NMR spectroscopic measurements.

Keywords: Multicomponent reactions, Gramine, Indole, N-Methylindole, Pyrimidine amine, Aryl aldehyde.

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Article Details

Year: 2021
Published on: 14 October, 2020
Page: [703 - 709]
Pages: 7
DOI: 10.2174/1570178617999201014165048
Price: $65

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