Chemical Composition, Antioxidant, Alpha-glucosidase Inhibitory, Anticholinesterase and Photoprotective Activities of the Aerial Parts of Schinus molle L.

Author(s): Mustapha M. Bouhenna*, Chawki Bensouici, Latifa Khattabi, Farid Chebrouk, Nabil Mameri

Journal Name: Current Bioactive Compounds

Volume 17 , Issue 6 , 2021


Article ID: e010621186885
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Graphical Abstract:


Abstract:

Background: Schinus molle L. is a medicinal and aromatic plant widely used in folk medicine and commonly found in Algeria and the Mediterranean region. In the present work, we investigated the in vitro antioxidant, anti-cholinesterase, α-glucosidase inhibitory and photoprotective potentials of the Schinus molle L. plant’s extract/fractions. The metabolite profile of Schinus molle L. was analyzed using RP-HPLC and GC-MS.

Methods: The antioxidant activity was assessed using different tests. The anticholinesterase activity was investigated by quantifying the acetylcholinesterase and butyrylcholinesterase inhibitory activities. The antidiabetic activity was investigated by α-glucosidase inhibition test, whereas photoprotective activity was evaluated by Sun Protection Factor (SPF) using spectrophotometry UV-Vis. The extracts were then subjected to RP-HPLC–PDA and GC–MS analysis.

Results: Ethyl acetate and butanol fractions with high contents of total phenolics and flavonoids exhibited the strongest antioxidant activity. Ethyl acetate extract exhibited considerable enzyme inhibition potential on acetylcholinesterase, butyrylcholinesterase and α-glucosidase with percentages of inhibition of 99.08 ± 0.79%, 100% and 98.80 ± 0.18%, respectively. Furthermore, the ethyl acetate fraction showed high photoprotective activity with the Sun Protection Factor (SPF) value = 38,26 ± 0.73. Three phenolic acids (gallic, tannic and vanillic acids) and five flavonoids (myricetin, apigenin, naringenin, rutin and quercetin) were identified with RP-HPLC–PDA.

Conclusion: These findings suggest that Schinus molle L. may be useful in the development of an alternative agent for oxidative stress, Alzheimer’s disease, diabetes and could be used as a natural sunscreen in pharmaceutics or cosmetic formulations.

Keywords: Schinus molle L. , antioxidant activity, acetylcholinesterase, butyrylcholinesterase, α-glucosidase, photoprotective activity.

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VOLUME: 17
ISSUE: 6
Year: 2021
Published on: 14 October, 2020
Article ID: e010621186885
Pages: 17
DOI: 10.2174/1573407216999201014153251
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