Recent Advances in On-Water Multicomponent Synthesis of Coumarin Derivatives

Author(s): Komal Chandrakar, Jeevan Lal Patel, S. P. Mahapatra, Santhosh Penta*

Journal Name: Current Organic Chemistry

Volume 24 , Issue 22 , 2020


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Abstract:

Coumarin-linked heterocycles represent privileged structural subunits and are welldistributed in naturally occurring compounds with immense biological activities. Multicomponent reactions (MCRs) are becoming a valuable tool for synthesizing structurally diverse molecular entities. On the other hand, the last year has seen a tremendous outburst in modifying chemical processes to make them sustainable for the betterment of our environment. The application of aqueous medium in organic synthesis is fulfilling some of the goals of ‘green and sustainable chemistry’ as it has some advantages over the traditional synthetic methods in terms of reaction rates, yields, purity of the products, product selectivity, etc. Hence, significant progress has been made in recent years. In the present review, we provide an overview of the recent developments of multicomponent synthesis of biologically relevant coumarin linked and fused heterocyclic compounds carried out from 2015 till today in an aqueous medium.

Keywords: Coumarin heterocycle’s, multicomponent reactions, one-pot synthesis, aqueous medium, green chemistry, sustainable chemistry, oxygen heterocycles, ultrasound reactions, nanocatalysis.

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Article Details

VOLUME: 24
ISSUE: 22
Year: 2020
Published on: 18 December, 2020
Page: [2601 - 2611]
Pages: 11
DOI: 10.2174/1385272824999201013164825
Price: $58

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