Coumarin-linked heterocycles represent privileged structural subunits and are welldistributed
in naturally occurring compounds with immense biological activities. Multicomponent
reactions (MCRs) are becoming a valuable tool for synthesizing structurally diverse
molecular entities. On the other hand, the last year has seen a tremendous outburst in modifying
chemical processes to make them sustainable for the betterment of our environment. The
application of aqueous medium in organic synthesis is fulfilling some of the goals of ‘green
and sustainable chemistry’ as it has some advantages over the traditional synthetic methods in
terms of reaction rates, yields, purity of the products, product selectivity, etc. Hence, significant
progress has been made in recent years. In the present review, we provide an overview of
the recent developments of multicomponent synthesis of biologically relevant coumarin
linked and fused heterocyclic compounds carried out from 2015 till today in an aqueous medium.
Keywords: Coumarin heterocycle’s, multicomponent reactions, one-pot synthesis, aqueous medium, green chemistry, sustainable chemistry,
oxygen heterocycles, ultrasound reactions, nanocatalysis.
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