Aims: This study aimed to assess the effect of Scorzanera undulata on plasma lipid profile.
Background: Scorzanera undulata (S. undulata) is a medicinal plant popularly used in the Moroccan
pharmacopeia as traditional medicine, particularly to treat diabetes mellitus.
Objective: The purpose of this study was to explore the effects of aqueous extract of Scorzanera undulata
tubers (AERSU) on lipid profile and atherogenic indices in Wistar rats. Biochemical parameters
such as Total Cholesterol (TC), triglycerides (TG), and low-and high-density lipoproteins-cholesterol
(LDL and HDL) were assessed. Furthermore, the in vitro antioxidant activity of AERSU
was also evaluated.
Methods: The effect of tubers aqueous extract (AERSU) of S. undulata (20 mg/kg) on plasma lipid
profile was investigated in normal and streptozotocin (STZ)-induced diabetic rats. The aqueous extract
was tested for its in vitro antioxidant activity. Besides, cardiovascular parameters were estimated.
Results: Treatment with AERSU significantly improved the weight in diabetic rats and decreased
plasma cholesterol, triglycerides, and LDL lipoproteins levels. Furthermore, the extract had a favorable
impact on the Atherogenic Index (AI) and Coronary Risk Index (CRI). In addition, AERSU
seems to possess a potent in vitro antioxidant activity.
Conclusion: The study demonstrates that aqueous Scorzanera undulate extract exhibits antidyslipidemic
and antioxidant activities.