Background: With the recent widespread use of over- the- counter drugs, there has been a noticeable increase
in the occurrence of gastrointestinal discomfort and peptic ulcer disease. However, peptic ulcer is a highly complex
disorder resulting from an imbalance between gstricdestructive and protective factors.
Objectives: To identifyrisk factors of peptic ulcer disease.
Methods: This study was organized at Al-Basra teaching hospital and Al Sader teaching hospital in Basrah city, Iraq.
Medical records and questionnaires filled by patients undergoing diagnostic and therapeutic upper gastrointestinal
endoscopies following their gastric discomfort complaints. Information related to patients, disease history and medication
history during six months prior to endoscopy procedures was collected.
Results: A total of 476 patients were identified, including 246 (51.7%) patients with endoscopically diagnosed peptic
ulcers and 230 (48.3%) patients without peptic ulcers. The population was predominately male and there were significant
differences between age groups.Smoking correlated with a high relative risk;however, alcohol drinking had no significant
role as a causative factor. The most extensively used drugs by patients who complained of peptic ulcers are NSAIDs, iron
supplements, corticosteroids, and antiplatelet agents. A small number of patients weretreated for hypertension and
diabetes, which were correlated with peptic ulcer risks. The presence of H-pylori infections was significantly associated
with peptic ulcer diagnosis.
Conclusion: The risk of peptic ulcer disease appeared to increase with chronic medication use and smoking, which
aggravatethe contributing risk by H-pylori infections.