Background: Diabetes mellitus is a metabolic disease that requires immediate attention.
Oxidative stress that leads to the generation of reactive oxygen species is a contributing factor to
the disease progression. Yttrium oxide nanoparticles (Y2O3 NPs) have a profound effect on alleviating
Methods: The literature related to Y2O3 NPs and oxidative stress has been thoroughly searched using
PubMed and Scopus databases and relevant studies from inception until August 2020 were included
in this scoping review.
Results: Y2O3 NPs altered oxidative stress-related biochemical parameters in different disease models
Conclusion: Although Y2O3 NPs are a promising antidiabetic agent due to their antioxidant and anti-
inflammatory properties, more studies are required to further elucidate the pharmacological and
toxicological properties of these nanoparticles.