Background: Acute appendicitis has been considered as the most common non-obstetric
indication that requires surgical intervention in pregnant women.
Objective: The aim of this study is to compare clinical manifestations and para-clinical indices
between pregnant and non-pregnant patients who have undergone appendectomy.
Methods: In this prospective cohort study, 57 pregnant and non-pregnant women presenting appendicitis
were compared in terms of diagnostic indicators, histopathological characteristics and laboratory
Results: Periumbilical region was the point of initiation of the pain; however, it was more prominent
in non-pregnant women. Similarly, tenderness in RLQ (right lower quadrant) of the abdomen
was more detectable in the non-pregnant group, and some of the cases showed no rebound tenderness.
Pregnant women with appendicitis presented an abnormal increase in the WBC count.
Conclusion: Pregnancy and appendicitis-related signs and symptoms have similarity among them.
Due to pregnancy, the physical examination might not present an exact diagnosis; therefore, pregnant
women susceptible to have appendicitis must undergo a complete and careful on-time examination
that includes ultrasound and labs.