2-Imino-2H-chromene-3-carbo(thio)amides are considered versatile compounds because
of their significance as building blocks in synthetic chemistry. In this review, we display all
the available synthetic methods for 2-imino-2H-chromene-3-carbo(thio)amides as well as their
reactions towards the different reagents. The presence of the imino and amide groups in these
compounds makes C-4 the only reactive site of the pyran ring with a unique reactivity that could
react with different reagents. The appropriate applications for the synthesis of condensed
chromene derivatives and their relevancy are reported. The reactions of 2-imino-2H-chromene-3-
carbo(thio)amides were divided into several categories depending on the used reagents in the reactions.
Keywords: Chromene, imino, amide, synthesis, reactivity, cyclization, nucleophiles, electrophiles.
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