The Synthesis and Chemistry of 2-Imino-2H-Chromene-3-Carbo(Thio) Amides

Author(s): Tarik E. Ali*, Hafez M. El-Shaaer, Somaia M. Abdel-Kariem, Mai S. A. Hussien, Ibrahim S. Yahia, Heba Y. Zahran

Journal Name: Mini-Reviews in Organic Chemistry

Volume 18 , Issue 6 , 2021

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Graphical Abstract:


2-Imino-2H-chromene-3-carbo(thio)amides are considered versatile compounds because of their significance as building blocks in synthetic chemistry. In this review, we display all the available synthetic methods for 2-imino-2H-chromene-3-carbo(thio)amides as well as their reactions towards the different reagents. The presence of the imino and amide groups in these compounds makes C-4 the only reactive site of the pyran ring with a unique reactivity that could react with different reagents. The appropriate applications for the synthesis of condensed chromene derivatives and their relevancy are reported. The reactions of 2-imino-2H-chromene-3- carbo(thio)amides were divided into several categories depending on the used reagents in the reactions.

Keywords: Chromene, imino, amide, synthesis, reactivity, cyclization, nucleophiles, electrophiles.

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Article Details

Year: 2021
Published on: 12 October, 2020
Page: [786 - 807]
Pages: 22
DOI: 10.2174/1570193X17999201012182420
Price: $65

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