Facile Synthesis of (E)-5-Styrylpyrimidines via Wittig Reaction Using Sodium Tripolyphosphate in Water

Author(s): Anilkumar S. Patel*, Sahaj A. Gandhi, Rajesh D. Modh, Urmila H. Patel, Yogesh T. Naliapara, Naval P. Kapuriya*

Journal Name: Letters in Organic Chemistry

Volume 18 , Issue 8 , 2021


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Abstract:

An inexpensive and eco-friendly Wittig olefination protocol has been developed to prepare novel (E)-5-styrylpyrimidines. The reaction of pyrimidine phosphonium ylide with different aryl/heteroaryl aldehydes underwent smoothly in the presence of sodium tripolyphosphate (STPP) in aqueous condition giving (E)-5-styrylpyrimidines (10a-t) in very high yields (77-96 %).

Keywords: Wittig reaction, (E)-5-styrylpyrimidines, green chemistry, water-mediated, sodium tripolyphosphate.

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Article Details

VOLUME: 18
ISSUE: 8
Year: 2021
Published on: 12 October, 2020
Page: [634 - 639]
Pages: 6
DOI: 10.2174/1570178617999201012181526
Price: $65

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