Extraction and Evaluation of Anti-inflammatory and Analgesic Activity of Mimosa rubicaulis in Swiss Albino Rats

(E-pub Ahead of Print)

Author(s): Roshani Gurung*, Sundar Adhikari, Niranjan Koirala, Kalpana Parajuli

Journal Name: Anti-Infective Agents
Formerly Anti-Infective Agents in Medicinal Chemistry


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Abstract:

Background: Pain and inflammation are major health problems. The adverse effect of synthetic drugs for the management of painful inflammatory conditions gives a strong motivation for researchers to develop newer drugs with a lesser side effect. Mimosa rubicaulis has been used traditionally in rheumatism, fungal infection, wound, fever, etc.

Objective: The objective was to evaluate the anti-inflammatory and analgesic activity of ethanolic stem extract of M. rubicaulis in Swiss albino rats.

Methods: The stem of M. rubicaulis were collected, subjected to double maceration using ethanol as a solvent. Then, swiss albino rats (n=72) were taken. An acute toxicity study was conducted using different doses of plant extract. The antiinflammatory activity (100 mg/kg, 250 mg/kg) was evaluated using the carrageenan-induced paw edema test. While, analgesic activity (100 mg/kg, 250 mg/kg) was evaluated using a hot plate and tail immersion method. The result was analyzed using a one-way Analysis of variance and post hoc analysis with the Tukey test.

Results: The acute toxicity study showed that the plant is safe for use in an animal model. The extract showed antiinflammatory activity by a reduction in paw edema volume i.e. 25%, and 48%. Similarly, analgesic activity was shown by an increase in latency of paw licking and tail withdrawal by 41%, 56% (hot plate method) and 39%, and 54% (Tail immersion method), p<0.05.

Conclusion: It can be concluded that ethanolic extract of Mimosa rubicaulis is safe and possesses both anti-inflammatory and analgesic activity.

Keywords: Analgesic activity, Anti-inflammatory activity, Carrageenan, Hot plate method, Tail immersion method, Mimosa rubicaulis

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Article Details

(E-pub Ahead of Print)
DOI: 10.2174/2211352518999201009125006
Price: $95

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