Background: Pain and inflammation are major health problems. The adverse effect of synthetic drugs for the
management of painful inflammatory conditions gives a strong motivation for researchers to develop newer drugs with a
lesser side effect. Mimosa rubicaulis has been used traditionally in rheumatism, fungal infection, wound, fever, etc.
Objective: The objective was to evaluate the anti-inflammatory and analgesic activity of ethanolic stem extract of M. rubicaulis in Swiss albino rats.
Methods: The stem of M. rubicaulis were collected, subjected to double maceration using ethanol as a solvent. Then, swiss
albino rats (n=72) were taken. An acute toxicity study was conducted using different doses of plant extract. The antiinflammatory activity (100 mg/kg, 250 mg/kg) was evaluated using the carrageenan-induced paw edema test. While, analgesic activity (100 mg/kg, 250 mg/kg) was evaluated using a hot plate and tail immersion method. The result was analyzed using a one-way Analysis of variance and post hoc analysis with the Tukey test.
Results: The acute toxicity study showed that the plant is safe for use in an animal model. The extract showed antiinflammatory activity by a reduction in paw edema volume i.e. 25%, and 48%. Similarly, analgesic activity was shown by
an increase in latency of paw licking and tail withdrawal by 41%, 56% (hot plate method) and 39%, and 54% (Tail immersion method), p<0.05.
Conclusion: It can be concluded that ethanolic extract of Mimosa rubicaulis is safe and possesses both anti-inflammatory
and analgesic activity.