Calcium-suppressed Technique in Dual-layer Detector Computed Tomography to Evaluate Knee Articular Cartilage

Author(s): Qinglin Meng, Mengqi Liu, Weiwei Deng, Ke Chen, Botao Wang, Xiaohuan Zhang, Zhiye Chen*

Journal Name: Current Medical Imaging
Formerly: Current Medical Imaging Reviews

Volume 17 , Issue 3 , 2021


Become EABM
Become Reviewer
Call for Editor

Graphical Abstract:


Abstract:

Background: Calcium-suppressed (CaSupp) technique involving spectral-based images has been used to observe bone marrow edema by removing calcium components from the image.

Objective: This study aimed to evaluate the knee articular cartilage using the CaSupp technique in dual-layer detector computed tomography (DLCT).

Methods: Twenty-eight healthy participants and two patients with osteoarthritis were enrolled, who underwent DLCT and magnetic resonance imaging (MRI) examination. CaSupp images were reconstructed from spectral-based images using a calcium suppression algorithm and were overlaid with conventional CT images for visual evaluation. The morphology of the knee cartilage was evaluated, and the thickness of the articular cartilage was measured on sagittal proton density-weighted and CaSupp images in the patellofemoral compartment.

Results: No abnormal signal or density, cartilage defect, and subjacent bone ulceration were observed in the lateral and medial femorotibial compartments and the patellofemoral compartment on MRI images and CaSupp images for the 48 normal knee joints. CaSupp images could clearly identify cartilage thinning, defect, subjacent bone marrow edema, and edema of the infrapatellar fat pad in the same way as MRI images in the three knee joints with osteoarthritis. A significant difference was found in the mean thickness of the patellar cartilage between MRI images and CaSupp images, while the femoral cartilage presented no significant difference in thickness between MRI images and CaSupp images in all 48 knee joints.

Conclusion: The present study demonstrated that CaSupp images could effectively be used to perform the visual and quantitative assessment of knee cartilage.

Keywords: Articular, calcium-suppressed technique, cartilage, knee joint, magnetic resonance imaging, spectral CT.

[1]
Baysal O, Baysal T, Alkan A, Altay Z, Yologlu S. Comparison of MRI graded cartilage and MRI based volume measurement in knee osteoarthritis. Swiss Med Wkly 2004; 134(19-20): 283-8.
[PMID: 15243849]
[2]
Wick MC, Kastlunger M, Weiss RJ. Clinical imaging assessments of knee osteoarthritis in the elderly: a mini-review. Gerontology 2014; 60(5): 386-94.
[http://dx.doi.org/10.1159/000357756] [PMID: 24751528]
[3]
Felson DT, Zhang Y. An update on the epidemiology of knee and hip osteoarthritis with a view to prevention. Arthritis Rheum 1998; 41(8): 1343-55.
[http://dx.doi.org/10.1002/1529-0131(199808)41:8<1343::AID-ART3>3.0.CO;2-9] [PMID: 9704632]
[4]
Brandt KD, Fife RS. Ageing in relation to the pathogenesis of osteoarthritis. Clin Rheum Dis 1986; 12(1): 117-30.
[PMID: 3522081]
[5]
Hannan MT, Felson DT, Pincus T. Analysis of the discordance between radiographic changes and knee pain in osteoarthritis of the knee. J Rheumatol 2000; 27(6): 1513-7.
[PMID: 10852280]
[6]
Vande Berg BC, Lecouvet FE, Malghem J. Frequency and topography of lesions of the femoro-tibial cartilage at spiral CT arthrography of the knee: a study in patients with normal knee radiographs and without history of trauma. Skeletal Radiol 2002; 31(11): 643-9.
[http://dx.doi.org/10.1007/s00256-002-0564-2] [PMID: 12395276]
[7]
Disler DG, McCauley TR, Kelman CG, et al. Fat-suppressed three-dimensional spoiled gradient-echo MR imaging of hyaline cartilage defects in the knee: comparison with standard MR imaging and arthroscopy. AJR Am J Roentgenol 1996; 167(1): 127-32.
[http://dx.doi.org/10.2214/ajr.167.1.8659356] [PMID: 8659356]
[8]
Vande Berg BC, Lecouvet FE, Poilvache P, Maldague B, Malghem J. Spiral CT arthrography of the postoperative knee. Semin Musculoskelet Radiol 2002; 6(1): 47-55.
[http://dx.doi.org/10.1055/s-2002-23163] [PMID: 11917270]
[9]
Mutschler C, Vande Berg BC, Lecouvet FE, et al. Postoperative meniscus: assessment at dual-detector row spiral CT arthrography of the knee. Radiology 2003; 228(3): 635-41.
[http://dx.doi.org/10.1148/radiol.2283020590] [PMID: 12881581]
[10]
Vande Berg BC, Lecouvet FE, Poilvache P, Maldague B, Malghem J. Spiral CT arthrography of the knee: technique and value in the assessment of internal derangement of the knee. Eur Radiol 2002; 12(7): 1800-10.
[http://dx.doi.org/10.1007/s00330-002-1491-2] [PMID: 12111072]
[11]
Kelcz F, Joseph PM, Hilal SK. Noise considerations in dual energy CT scanning. Med Phys 1979; 6(5): 418-25.
[http://dx.doi.org/10.1118/1.594520] [PMID: 492076]
[12]
Fulwadhva UP, Wortman JR, Sodickson AD. Use of dual-energy CT and iodine maps in evaluation of bowel disease. Radiographics 2016; 36(2): 393-406.
[http://dx.doi.org/10.1148/rg.2016150151] [PMID: 26963452]
[13]
Wortman JR, Uyeda JW, Fulwadhva UP, Sodickson AD. Dual-energy CT for abdominal and pelvic trauma. Radiographics 2018; 38(2): 586-602.
[http://dx.doi.org/10.1148/rg.2018170058] [PMID: 29528816]
[14]
Li M, Zheng X, Gao F, Xiao L, Hua Y. Spectral CT imaging of intranodular hemorrhage in cases with challenging benign thyroid nodules. Radiol Med (Torino) 2016; 121(4): 279-90.
[http://dx.doi.org/10.1007/s11547-015-0601-6] [PMID: 26612322]
[15]
Liu X, Ouyang D, Li H, et al. Papillary thyroid cancer: dual-energy spectral CT quantitative parameters for preoperative diagnosis of metastasis to the cervical lymph nodes. Radiology 2015; 275(1): 167-76.
[http://dx.doi.org/10.1148/radiol.14140481] [PMID: 25521777]
[16]
Li R, Li J, Wang X, Liang P, Gao J. Detection of gastric cancer and its histological type based on iodine concentration in spectral CT. Cancer Imaging 2018; 18(1): 42.
[http://dx.doi.org/10.1186/s40644-018-0176-2] [PMID: 30413174]
[17]
Wu F, Zhou H, Li F, Wang JT, Ai T, Spectral CT. Spectral CT imaging of lung cancer: quantitative analysis of spectral parameters and their correlation with tumor characteristics. Acad Radiol 2018; 25(11): 1398-404.
[http://dx.doi.org/10.1016/j.acra.2018.04.017] [PMID: 29752156]
[18]
Yang F, Dong J, Wang X, Fu X, Zhang T. Non-small cell lung cancer: Spectral computed tomography quantitative parameters for preoperative diagnosis of metastatic lymph nodes. Eur J Radiol 2017; 89: 129-35.
[http://dx.doi.org/10.1016/j.ejrad.2017.01.026] [PMID: 28267528]
[19]
Jacobsen MC, Schellingerhout D, Wood CA, et al. Intermanufacturer Comparison of Dual-Energy CT Iodine Quantification and Monochromatic Attenuation: A Phantom Study. Radiology 2018; 287(1): 224-34.
[http://dx.doi.org/10.1148/radiol.2017170896] [PMID: 29185902]
[20]
Kellock TT, Nicolaou S, Kim SSY, et al. Detection of bone marrow edema in nondisplaced hip fractures: utility of a virtual noncalcium dual-energy CT application. Radiology 2017; 284(3): 798-805.
[http://dx.doi.org/10.1148/radiol.2017161063] [PMID: 28301779]
[21]
Schwaiger BJ, Gersing AS, Hammel J, et al. Three-material decomposition with dual-layer spectral CT compared to MRI for the detection of bone marrow edema in patients with acute vertebral fractures. Skeletal Radiol 2018; 47(11): 1533-40.
[http://dx.doi.org/10.1007/s00256-018-2981-x] [PMID: 29802531]
[22]
Kaup M, Wichmann JL, Scholtz JE, et al. Dual-Energy CT-based Display of Bone Marrow Edema in Osteoporotic Vertebral Compression Fractures: Impact on Diagnostic Accuracy of Radiologists with Varying Levels of Experience in Correlation to MR Imaging. Radiology 2016; 280(2): 510-9.
[http://dx.doi.org/10.1148/radiol.2016150472] [PMID: 26928067]
[23]
Diekhoff T, Hermann KG, Pumberger M, Hamm B, Putzier M, Fuchs M. Dual-energy CT virtual non-calcium technique for detection of bone marrow edema in patients with vertebral fractures: A prospective feasibility study on a single- source volume CT scanner. Eur J Radiol 2017; 87: 59-65.
[http://dx.doi.org/10.1016/j.ejrad.2016.12.008] [PMID: 28065376]
[24]
Wang CK, Tsai JM, Chuang MT, Wang MT, Huang KY, Lin RM. Bone marrow edema in vertebral compression fractures: detection with dual-energy CT. Radiology 2013; 269(2): 525-33.
[http://dx.doi.org/10.1148/radiol.13122577] [PMID: 23801776]
[25]
Petritsch B, Kosmala A, Weng AM, et al. Vertebral compression fractures: third-generation dual-energy CT for detection of bone marrow edema at visual and quantitative analyses. Radiology 2017; 284(1): 161-8.
[http://dx.doi.org/10.1148/radiol.2017162165] [PMID: 28240561]
[26]
Neuhaus V, Lennartz S, Abdullayev N, et al. Bone marrow edema in traumatic vertebral compression fractures: Diagnostic accuracy of dual-layer detector CT using calcium suppressed images. Eur J Radiol 2018; 105: 216-20.
[http://dx.doi.org/10.1016/j.ejrad.2018.06.009] [PMID: 30017283]
[27]
Wu H, Zhang G, Shi L, et al. Axial spondyloarthritis: dual-energy virtual noncalcium CT in the detection of bone marrow edema in the sacroiliac joints. Radiology 2019; 290(1): 157-64.
[http://dx.doi.org/10.1148/radiol.2018181168] [PMID: 30351251]
[28]
Van Breuseghem I. Ultrastructural MR imaging techniques of the knee articular cartilage: problems for routine clinical application. Eur Radiol 2004; 14(2): 184-92.
[http://dx.doi.org/10.1007/s00330-003-2142-y] [PMID: 14600779]
[29]
Hayes CW, Jamadar DA, Welch GW, et al. Osteoarthritis of the knee: comparison of MR imaging findings with radiographic severity measurements and pain in middle-aged women. Radiology 2005; 237(3): 998-1007.
[http://dx.doi.org/10.1148/radiol.2373041989] [PMID: 16251398]


Rights & PermissionsPrintExport Cite as

Article Details

VOLUME: 17
ISSUE: 3
Year: 2021
Published on: 08 October, 2020
Page: [433 - 438]
Pages: 6
DOI: 10.2174/1573405616666201008150644
Price: $65

Article Metrics

PDF: 32
HTML: 1