Aims: The study aimed to assess the antihyperglycemic effect of Cleome arabica.
Background: Cleome arabica L. or spider flower belongs to the Capparidaceae family and it is
used for treating inflammation and diabetes mellitus in traditional medicine.
Objective: This study aimed to evaluate the antihyperglycemic activity and acute toxicity of the
aqueous extract of Cleome arabica L (CAAE).
Methods: The acute toxicity of CAAE was evaluated at doses of 500, 1000, or 2000 mg/kg. Parallelly,
body weight, signs of toxicity, and/or mortality were observed for 14 days. The effect of oral
administration of Cleome arabica aqueous extract (CAAE) at a dose of 100 mg/kg on glycemia
was performed in normal and diabetic rats. Additionally, histopathological structure of the liver,
phytochemical screening and in vitro antioxidant activity were studied.
Results: The acute toxicity test revealed that all treated rats survived, and no change in body
weight was observed. The results demonstrated that CAAE exhibited a significant antihyperglycemic
effect in diabetic rats. Furthermore, the plant extract ameliorated the liver histology in diabetic
rats with a concomitant antioxidant activity.
Conclusion: This study shows that Cleome arabica is partly safe, and its LD50 seems to be greater
than 5000 mg/kg. Cleome Arabica has a favorable effect against diabetes, which could be due to
the presence of numerous secondary metabolites and by the protection of hepatocytes.