Glioblastoma (GBM) is a fatal type of brain cancer or primary glial neoplasm, mostly
targeting aged populations. The average survival is only 15 months from the date of occurrence. It
is often observed that, the invasive nature of the tumour is the main reason for poor prognosis and
strong recurrence of GBM in patients even after prescribed treatments. Despite all types of therapies,
it is necessary to understand the various molecular mechanisms and signalling pathways to
identify targets for GBM treatment. This compilation is specifically designed to discuss Wnt signalling
and Hedgehog-GLI1 pathways, which have positive and negative regulation against GBM.
The recent research finding associated with different signalling pathways for GBM has also been
discussed within this article.
Keywords: Glioblastoma multiforme (GBM), wnt signalling, hedgehog-gLI1, rho/rhzo kinase (ROCK), β-catenin, neoplasm.Glioblastoma multiforme (GBM), wnt signalling, hedgehog-gLI1, rho/rhzo kinase (ROCK), β-catenin, neoplasm.
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Ylivinkka I. Netrins in glioma biology: Regulators of tumor cell proliferation, motility and stemness. University of Helsinki 2017.
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