Extracellular vesicles (EVs) of endocytic origin are known as exosomes. These vesicles
are released by cells and are found in biofluids, such as saliva, urine, and plasma. These vesicles
are made up of small RNA, DNA, proteins, and play a vital role in many physiological processes.
In the central nervous system (CNS), they participate in various physiological processes such as
stress of nerve cells, communication between the cells, synaptic plasticity, and neurogenesis. The
role of exosomes in depression needs to be explored further. It is known that exosomes can cross
the blood brain barrier (BBB), which is made up of glial cells astrocytes. One of the advantages of
these vesicles is that they are able to transfer macromolecules like DNA, protein, mRNAs, and miRNAs
to recipient cells. This review focuses on the potential role of exosomes in depression and
their utilization as a treatment option or diagnostic tool of depression.