Proteomic Analysis of Huntington’s Disease

Author(s): Shobhit Kumar*, Priyanka Singh, Shrestha Sharma, Javed Ali, Sanjula Baboota, Faheem Hyder Pottoo

Journal Name: Current Protein & Peptide Science

Volume 21 , Issue 12 , 2020


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Abstract:

Huntington’s disease (HD) is a neurodegenerative disease that is genetically inherited through an autosomal dominant gene located on chromosome 4. HD is caused by DNA mutation (generally 37 or more repetition of CAG nucleotides) that leads to an excessive stretch of glutamine residues. However, the main pathogenesis pathway resulted by polyglutamine expansion in mutant HD is unknown. The characteristics of this disease mostly appear in adults. Patients who suffer from this disease have shown an inability to control physical movements, emotional problems, speech disturbance, dementia, loss of thinking ability and death occurs between 15-20 years from the time of symptomatic onset. This review article suggested that investigation of mutation in the HD gene can be done by proteomic analysis such as mass spectroscopy, gel electrophoresis, western blotting, chromatographic based technology, and X-ray crystallography. The primary aim of proteomics is to focus on the molecular changes occurring in HD, there by enhancing the effectiveness of treatment.

Keywords: Electrophoresis, huntington’s disease, mass spectroscopy, western blotting, mutation, proteomics.

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Article Details

VOLUME: 21
ISSUE: 12
Year: 2020
Published on: 06 October, 2020
Page: [1218 - 1222]
Pages: 5
DOI: 10.2174/1389203721666201006160327
Price: $65

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