Diabetic nephropathy (DN) is a common microvascular complication of diabetes
and one of the leading causes of end-stage renal disease. Tubular damage is an early change
and characteristic of DN, and mitochondrial dysfunction plays an important role in the development
of DN. Therefore, the timely removal of damaged mitochondria in tubular cells is an
effective treatment strategy for DN. Mitophagy is a type of selective autophagy that ensures
the timely elimination of damaged mitochondria to protect cells from oxidative stress. In this
review, we summarize our understanding of mitochondrial dysfunction and dynamic disorders
in tubular cells in DN and the molecular mechanism of mitophagy. Finally, the role of mitophagy
in DN and its feasibility as a therapeutic target for DN are discussed.
Keywords: Mitophagy, Diabetic nephropathy, Tubular cells, Mitochondria, Oxidative stress, Autophagy.
Rights & PermissionsPrintExport