Background: COVID-19 debilitated communities globally in varying complexities and capacities
in recent months.
Objective: The epigenetic changes in the COVID-19 patients were discussed in this article to explore various
processes contributing to disease severity and elevation of risk due to infection.
Methods: Percentages of hospitalization, with and without intensive care, in the presence of diseases with increased
ACE2 expression, were compared, based on the best available data. Further analysis compared two
different age groups, 19-64 and ≥65 years of age.
Result & Conclusion: The COVID-19 disease is observed to be the most severe in the 65 and-higher-age
group with pre-existing chronic conditions. This observational study is a nonexperimental empirical investigation
of the outcomes of COVID-19 in different patient groups. Results are promising for conducting clinical
trials with intervention groups. To ultimately succeed in disease prevention, researchers and clinicians must
integrate epigenetic mechanisms to generate valid prescriptions for global well-being.