Aptamers as Anti-Infective Agents
Pp. 232-253 (22)
Muhammad Ali Syed, Nayab Ali, Bushra Jamil and Ammar Ahmed
Rapidly emerging drug resistance in all classes of pathogenic
microorganisms has become a challenging task and a global health issue in recent
years. There are very limited alternative options available to cure infectious diseases, as
the rate of rise in drug resistance in infectious agents is higher than the arrival of new
antimicrobial drugs. There is a dire need to look for new types of anti-infective agents,
besides looking for new antibiotics. One of the promising types of antimicrobial agents
is aptamers, synthesized through systematic evolution of ligands by exponential
enrichment (SELEX) technique. Aptamers hold a significant promise for the treatment
of various infectious diseases in the future. In the recent past, a number of successful
attempts have been made to select and apply aptamers for the detection and binding of
infectious agents and their products for therapeutic purposes. This chapter presents a
basic introduction to aptamers and their application as anti-infective agents.
Aptamers, Antibiotics, Drug Resistance, Infectious Diseases,
Systemic Evolution of Ligands by Exponential Enrichment (SELEX).
Department of Microbiology, The University of Haripur, Haripur, Pakistan.