Quinacrine is an older antimalarial drug that remains in use for a variety of illnesses including treatment
resistant giardiasis. We report a patient with no prior psychiatric history who developed mild, prodromal psychiatric
symptoms when treated with quinacrine for treatment resistant giardiasis. Symptoms resolved when the drug was stopped,
recurred with greater severity (requiring involuntary psychiatric hospitalization) when restarted and promptly resolved
again when finally stopped. Although quinacrine remains in use today, providers may be unaware of its potential for
serious neuropsychiatric toxicity.
Keywords: Quinacrine, quinolines, psychosis, adverse drug reaction, case report
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