Dynamic Behavior of Biomaterials Uncovered by Cryo-electron Microscopy

Author(s): Yimin Zhao, Yizhen Zhao, Bingquan Peng, Lei Zhang*

Journal Name: Combinatorial Chemistry & High Throughput Screening
Accelerated Technologies for Biotechnology, Bioassays, Medicinal Chemistry and Natural Products Research

Volume 24 , Issue 7 , 2021

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Structural biology develops rapidly with time. The static structure analysis of biomaterials is not enough to satisfy the studies of their functional mechanisms, with a huge obstacle for the dynamic process of biological complexes. The rapid development of cryo-electron microscopy (cryo-EM) technology makes it possible to observe the near-atomic resolution structures and dynamic nature of biological macromolecules, in the fields of dynamic characteristics of proteins, protein-protein interactions, molecular recognition, and structure-based design. In this review, we systematically elaborate the contribution of cryo-EM technology in the field of biomaterials such as ribosome motion, membrane protein structure and conformational space, dynamic transmission within the plasma membrane and clinical applications. We also put forward a new standpoint in the development of cryo-EM technology.

Keywords: Cryo-electron microscopy, ribosome translocation, conformational changes, structure-based design, CMOS, electron dose.

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Article Details

Year: 2021
Published on: 04 October, 2020
Page: [1007 - 1016]
Pages: 10
DOI: 10.2174/1386207323666201005100653
Price: $65

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