Background: Rheumatoid Arthritis (RA) is a common connective tissue disease, characteristic
of chronic and invasive synovitis in single or multiple joints and vasculitis. RA is a heterogeneous
disease with unclear pathogenesis. Therefore, exploring the etiology and pathogenesis of the disease is
essential for identifying new promising treatment strategies for RA. Accumulated data have implicated
the significant role of non-coding RNA in RA, some of which are demonstrated to regulate inflammation
and autoimmunity in RA through the Toll-Like Receptor (TLR) signaling pathway. To clarify the
mechanism of non-coding RNA regulating the generation of proinflammatory mediators is helpful for
understanding the pathogenesis of RA. Moreover, these well established non-coding RNAs can serve
as novel biotargets for RA diagnosis and treatment.
Conclusion: Here, we summarize currently available data on non-coding RNAs, TLRs, and the underlying
molecular mechanisms in RA. This review will provide insight into the potential use of noncoding
RNA as disease diagnosis and treatment markers for RA.