Recent Update on the Anti-infective Potential of β-carboline Analogs

Author(s): Faheem, Banoth Karan Kumar, Kondapalli Venkata Gowri Chandra Sekhar, Selvaraj Kunjiappan, Joazaizulfazli Jamalis, Rafael Balaña-Fouce, Murugesan Sankaranarayanan*

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 21 , Issue 4 , 2021


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Abstract:

β-Carboline, a naturally occurring indole alkaloid, holds a momentous spot in the field of medicinal chemistry due to its myriad of pharmacological actions like anticancer, antiviral, antibacterial, antifungal, antileishmanial, antimalarial, neuropharmacological, anti-inflammatory and antithrombotic among others. β-Carbolines exhibit their pharmacological activity via diverse mechanisms. This review provides a recent update (2015-2020) on the anti-infective potential of natural and synthetic β-carboline analogs focusing on its antibacterial, antifungal, antiviral, antimalarial, antileishmanial and antitrypanosomal properties. In cases where enough details are available, a note on its mechanism of action is also added.

Keywords: β-Carboline, PYRIDO indole, antibacterial, antifungal, antiviral, antiprotozoal.

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Article Details

VOLUME: 21
ISSUE: 4
Year: 2021
Published on: 16 February, 2021
Page: [398 - 425]
Pages: 28
DOI: 10.2174/1389557520666201001130114
Price: $65

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