Depression is a widespread and persistent psychiatric disease. Due to various side effects and no curative
treatments of conventional antidepressant drugs, botanical medicines have attracted considerable attention
as a complementary and alternative approach. The pathogenesis of depression is quite complicated and unclear.
Metabolomics is a promising new technique for the discovery of novel biomarkers for exploring the potential
mechanisms of diverse diseases and assessing the therapeutic effects of drugs. In this article, we systematically
reviewed the study of botanical medicine for the treatment of depression using metabolomics over a period
from 2010 to 2019. Additionally, we summarized the potential biomarkers and metabolic pathways associated
with herbal medicine treatment for depression. Through a comprehensive evaluation of herbal medicine as
novel antidepressants and understanding of their pharmacomechanisms, a new perspective on expanding the application
of botanical medicines for the treatment of depression is provided.
Keywords: Antidepressants, phytochemicals, herbal formula, metabolomics, metabolic biomarkers, assessment.
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