Background: Colon cancer is responsible for increasing the death rate worldwide.
Commonly used anticancer drugs have various side effects and their clinical usage must be
restricted due to their toxicity.
Objective: The present research aimed to evaluate the anticancer potential of Lepidium sativum L.
(LS) seeds aqueous extract against azoxymethane/dextran sodium sulfate (AOM/DSS) inducedcolon
cancer in male albino mice.
Methods: Low (200 mg/kg) and high (400 mg/kg) doses of LS seeds extract were used to treat
induced colon cancer in different stages.
Results: The present results report that LS treatment for mice with colon cancer especially in high
dose, decreases colon polyps/tumor incidence and size, tissues disorder, expression of P53 and
increases apoptosis in colon tissue. Moreover, LS decreases micronucleus induction in
polychromatic (PCE), increases PCE/normochromatic erythrocytes ratio and decreases the
percentage of sperm abnormalities.
Conclusion: The present study reports anticancer potential of LS for induced colorectal cancer
mice by ameliorating the inflammatory steps of colon.