SeDeM Expert System, an Innovative Tool for Developing Directly Compressible Tablets: A Review

Author(s): Inderbir Singh*, Ajay Kumar Thakur, Rajni Bala, Reecha Madan

Journal Name: Current Drug Research Reviews
(Formerly Current Drug Abuse Reviews)

Volume 13 , Issue 1 , 2021

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Graphical Abstract:


Background: SeDeM (Sediment Delivery Model) expert system is a preformulation tool employed for evaluating direct compression suitability of various excipients. SeDeM is a 12 parameters derived diagram and SeDeM-ODT (Sediment Delivery Model-Orodispersible tablets) is a 15 parameters derived diagram that can be used as a research tool for reducing the product development time. The best possible excipients for a specified pharmaceutical active ingredient could be screened for direct compression suitability.

Objective: SeDeM expert system has been successfully used and implemented for characterizing galenic properties of pharmaceutical excipients, direct compression suitability of excipients, development of ODT formulations, development of sustained-release formulations, and development of tablets of taste-masked drugs.

Conclusion: In the present review paper, the development and applications of SeDeM and SeDeMODT systems have been discussed in detail.

Keywords: SeDeM, SeDeM-ODT, direct compression, excipients, tablets, application.

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Article Details

Year: 2021
Published on: 12 April, 2021
Page: [16 - 24]
Pages: 9
DOI: 10.2174/2589977512666200928113716
Price: $65

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PDF: 26