Background: SeDeM (Sediment Delivery Model) expert system is a preformulation tool
employed for evaluating direct compression suitability of various excipients. SeDeM is a 12 parameters
derived diagram and SeDeM-ODT (Sediment Delivery Model-Orodispersible tablets) is a 15
parameters derived diagram that can be used as a research tool for reducing the product development
time. The best possible excipients for a specified pharmaceutical active ingredient could be
screened for direct compression suitability.
Objective: SeDeM expert system has been successfully used and implemented for characterizing
galenic properties of pharmaceutical excipients, direct compression suitability of excipients, development
of ODT formulations, development of sustained-release formulations, and development of
tablets of taste-masked drugs.
Conclusion: In the present review paper, the development and applications of SeDeM and SeDeMODT
systems have been discussed in detail.