Thyroid carcinoma represents a complex pathology that can still be considered a medical
challenge, despite having a better prognosis and life expectancy than most other neoplasms; also
the scenario of multiple malignancies involving thyroid cancer is nowadays a common reality.
Materials and methods: We reviewed the literature regarding the aggressive presentation of
synchronous thyroid and breast cancer. In the current paper, we report the case of a 59 years-old
woman, diagnosed with invasive ductal breast carcinoma and papillary thyroid carcinoma, presenting
a natural history of both aggressive synchronous tumors. At the moment of hospitalization, the
diagnosis was breast carcinoma with multiple secondary lesions, suggestive of lung and bone metastases,
and nodular goiter.
Results: Searching the literature in PUBMED with the terms “thyroid
carcinoma and synchronous breast carcinoma, we found 86 studies; introducing the term “aggressive,”
the result included 4 studies, among which, none showed to be relevant to the terms aggressive
and synchronous. A similar search was done in SCOPUS finding 92 documents and after introducing
the term aggressive, the number of papers was 8, none including the literature on synchronous
aggressive metastatic thyroid and breast carcinoma. A majority of imaging diagnostic tools
were used in this particular medical case in order to ensure the best potential outcome. The final diagnosis
was papillary thyroid carcinoma with lung and unusual multiple bone metastases and
synchronous invasive ductal breast carcinoma with subcutaneous metastases.
Conclusion: The case illustrates the challenges in the correct assessment of oncologic patients, despite the advances in
medical imaging and technologies and underlines the essential role of nuclear medicine procedures
in the diagnostic and therapy protocols.