Title:Peaceful Existence of Tumor Cells with Their Non-malignant Neighbors: The Trade of Tumor Cells with Tumor Microenvironment
VOLUME: 14 ISSUE: 4
Author(s):Amirhosein Maali, Mohammad Sarfi, Mohammad Mirzakhani, Golnaz Goodarzi, Hosein Maghsoudi, Mahmood Maniati, Sadra Samavarchi Tehrani* and Durdi Qujeq*
Affiliation:Student Research Committee, Babol University of Medical Sciences, Babol, Department of Clinical Biochemistry, School of Medicine, Tehran University of Medical Sciences, Tehran, Student Research Committee, Babol University of Medical Sciences, Babol, Department of Clinical Biochemistry, School of Medicine, Tehran University of Medical Sciences, Tehran, Student Research Committee, Babol University of Medical Sciences, Babol, Department of English, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Department of Clinical Biochemistry, School of Medicine, Tehran University of Medical Sciences, Tehran, Department of Clinical Biochemistry, Babol University of Medical Sciences, Babol
Keywords:Tumor microenvironment, miRNA, signaling pathways, cancer biochemistry, cross-talk. tumor
cells, tumor-associated exosomes.
Abstract:Tumor cell growth and survival are the outcomes of communication between tumor
cells and tumor microenvironment (TME). In other words, tumor cell growth and survival
are greatly affected by the interaction between adjacent cells and tumor cells. In this
paper, we review the recent advances in studies of TME, including metabolic interplays between
tumor cells and their non-malignant neighbors (peaceful interaction and autophagy),
trades of signaling pathways (approach to most important ones; cytokine pathway, NF-kB
pathway, intra-tumoral hypoxia, oxidative stress, and nitric oxide-depended pathways),
miRNAs (as the regulatory molecules which are present in TME), and Tumor-associated
Exosomes (TAEs). Characterization of TME bio-molecules, nutrient changes, and cellular
and molecular interactions help to clarify the progression of cancer and find novel targets for
the treatment of cancer.
