In today’s society, healthy skin and a beautiful appearance are considered the foundation of general
well-being. The skin is the largest organ of the body and plays an important role in protecting it against various
hazards such as environmental, physical, chemical, and biological hazards. These factors include mediators that
lead to oxidation reactions that produce reactive oxygen/nitrogen species and additional oxidants in the skin
cells. An increase in oxidants beyond the antioxidant capacity of its defense system causes oxidative stress and
chronic inflammation in the body. This response can cause further disruption of collagen fibers and hinder the
functioning of skin cells that may result in the development of various skin diseases including psoriasis, atopic
dermatitis, and aging. In this review, we summarized the present information related to the role of oxidative
stress in the pathogenesis of dermatological disorders, and its impact on physical beauty and the daily lives of
patients. We also discussed how molecular hydrogen exhibits a therapeutic effect against skin diseases via its effects
on oxidative stress. Furthermore, findings from this summary review indicate that molecular hydrogen
might be an effective treatment modality for the prevention and treatment of skin-related illnesses.
Keywords: Skin, beauty, skin diseases, oxidants, dermatological disorder, molecular hydrogen, oxidative stress.
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