Inflammation Drives Alzheimer's Disease: Emphasis on 5-lipoxygenase Pathways

Author(s): Aisha Siddiqui, Sayeed Akhtar*, Zahoor Shah, Iekhsan Othman, Yatinesh Kumari*

Journal Name: Current Neuropharmacology

Volume 19 , Issue 6 , 2021

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Graphical Abstract:


It is a known fact that inflammation affects several physiological processes, including the functioning of the central nervous system. Additionally, impairment of lipid mechanisms/pathways have been associated with a number of neurodegenerative disorders and Alzheimer’s Disease (AD) is one of them. However, much attention has been given to the link between tau and beta- amyloid hypothesis in AD pathogenesis/prognosis. Increasing evidences suggest that biologically active lipid molecules could influence the pathophysiology of AD via a different mechanism of inflammation. This review intends to highlight the role of inflammatory responses in the context of AD with the emphasis on biochemical pathways of lipid metabolism enzyme, 5-lipoxygenase (5- LO).

Keywords: Alzheimer's Diseases, 5-lipoxygenase, Neuro Inflammation, Neurodegeneration, Lipid Molecule, Arachidonic Acid.

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Article Details

Year: 2021
Published on: 24 September, 2020
Page: [885 - 895]
Pages: 11
DOI: 10.2174/1570159X18666200924122732
Price: $65

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