Discovery and Development of Inflammatory Inhibitors from 2-Phenylchromonone (Flavone) Scaffolds

Author(s): Chen Xu, Meng-Yuan Fang, Ke Wang, Jing Liu, Guang-Ping Tai, Zhao-Ting Zhang*, Ban-Feng Ruan*

Journal Name: Current Topics in Medicinal Chemistry

Volume 20 , Issue 28 , 2020


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Graphical Abstract:


Abstract:

Flavonoids are compounds based on a 2-phenylchromonone scaffold. Flavonoids can be divided into flavonoids, flavonols, dihydroflavones, anthocyanins, chalcones and diflavones according to the oxidation degree of the central tricarbonyl chain, the connection position of B-ring (2-or 3-position), and whether the tricarbonyl chain forms a ring or not. There are a variety of biological activities about flavonoids, such as anti-inflammatory activity, anti-oxidation and anti-tumor activity, and the antiinflammatory activity is apparent. This paper reviews the anti-inflammatory activities and mechanisms of flavonoids and their derivatives reported in China and abroad from 2011 till date (2011-2020), in order to find a good drug scaffold for the study of anti-inflammatory activities.

Keywords: Natural products, Flavonoids, Anti-inflammatory activity, Anti-inflammatory mechanism, 2-phenylchromonone scaffold, Drug.

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