Background: In recent years, the emergence of stimuli-responsive nanoparticles has made drug delivery
more efficient. As an intelligent and effective targeted delivery platform, it can reduce the side effects
generated during drug transportation while enhancing the treatment efficacy. The stimuli-responsive nanoparticles
can respond to different stimuli at corresponding times and locations to deliver and release their drugs and
associated therapeutic effects.
Objective: This review aims to inform researchers on the latest advances in the application of dual-stimuli responsive
nanoparticles in precise drug delivery, with special attention to their design, drug release properties,
and therapeutic effects. Syntheses of nanoparticles with simultaneous or sequential responses to two or more
stimuli (pH-redox, pH-light, redox-light, temperature-magnetic, pH-redox-temperature, redox-enzyme-light,
etc.) and the applications of such responsivity properties for drugs control and release have become a hot topic
of recent research.
Methods: A database of relevant information for the production of this review was sourced, screened and analyzed
from Pubmed, Web of Science, SciFinder by searching for the following keywords: “dual-stimuli responsive”,
“controlled release”, “cancer therapy”, “synergistic treatment”.
Results: Notably, the nanoparticles with dual-stimuli responsive function have an excellent control effect on
drug delivery and release, playing a crucial part in the treatment of tumors. They can improve the encapsulation
and delivery efficiency of hydrophobic chemotherapy drugs, combine chemo-photothermal therapies, apply
imaging function in the diagnosis of tumors and even conduct multi-drug delivery to overcome Multi-Drug
Conclusion: With the development of smart dual-stimuli responsive nanoparticles, cancer treatment methods
have become more diverse and effective. All the stimuli-responsive nanoparticles functionalities exhibit their
characteristics individually within the single nanosystem.