Medicinal Chemistry for Pharmacy Students

Medicinal Chemistry for Pharmacy Students

Volume: 2

Medicinal Chemistry of Drugs Affecting the Nervous System

The primary objective of this 4-volume book series is to educate PharmD students on the subject of medicinal chemistry. The book set serves as a reference guide to pharmacists on aspects of the ...
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Antiepileptic Drugs

Pp. 249-299 (51)

Tamer E. Fandy, Michaela Leffler and M. O. Faruk Khan


This chapter is a comprehensive account of the medicinal chemistry of antiepileptic drugs. It provides the mechanism of drug action and detailed structureactivity relationships of the antiepileptic and related drugs and their clinical relevance to give the knowledge base for pharmacists. After a study of this chapter, students will be able to:

• Relate principles of gamma amino butyric acid (GABA) biosynthesis, storage, transport, and metabolism to the action of antiepileptic drugs.

• Define and differentiate among different types of seizures and epilepsy.

• Illustrate mechanism of action, SAR, metabolites, and clinical considerations of different classes of antiepileptic drugs including: barbiturates, hydantoins, oxazolidinediones, succinimides, amides, benzodiazepines, valproic acid and its derivatives, GABA-analogs, and miscellaneous compounds.


Antiepileptic drugs, Agonists and Antagonists of GABA and different Ion Channels, Clinical use of Antiepileptic Drugs, Drug Receptor Interaction, GABA, Structure Activity Relationship.


School of Pharmacy, University of Charleston, Charleston, WV 25304, USA.