Medicinal Chemistry for Pharmacy Students

Medicinal Chemistry for Pharmacy Students

Volume: 2

Medicinal Chemistry of Drugs Affecting the Nervous System

The primary objective of this 4-volume book series is to educate PharmD students on the subject of medicinal chemistry. The book set serves as a reference guide to pharmacists on aspects of the ...
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Sedatives, Hypnotics and Anxiolytics

Pp. 207-248 (42)

Donald Sikazwe


The major objective of this chapter is to concisely explain and equip pharmacy students with the chemical and pharmacological knowledge of traditional/ conventional and newer sedative-hypnotics and anxiolytics, that is, barbiturates, benzodiazepines and non-benzodiazepine agents. Upon studying this book chapter, students will be able to:

• Categorize Chemically/Pharmacologically sedative-hypnotics and anxiolytics.

• Explain the mechanisms by which barbiturates, benzodiazepines, and nonbenzodiazepine sedative-hypnotics and anxiolytics exert their pharmacological effects.

• Summarize the benzodiazepine and barbiturate structure-activity relationships (SAR).

• Describe the key pharmacokinetic (ADMET) characteristics of individual drug molecules.


Anxiolytics, Barbiturates, Benzodiazepines, GABA receptor, GABAA receptor agonists, Hypnotics, Inverse agonists and antagonists, Orexins, Partial agonists, Ramelteon, Sedatives, Structure-activity relationships, Z-drugs.


Department of Pharmaceutical Sciences, Feik School of Pharmacy, University of the Incarnate Word, San Antonio, TX, USA.