Medicinal Chemistry for Pharmacy Students

Medicinal Chemistry for Pharmacy Students

Volume: 2

Medicinal Chemistry of Drugs Affecting the Nervous System

The primary objective of this 4-volume book series is to educate PharmD students on the subject of medicinal chemistry. The book set serves as a reference guide to pharmacists on aspects of the ...
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Drugs Affecting Adrenergic System

Pp. 59-108 (50)

M. O. Faruk Khan and Les Ramos


This chapter is a comprehensive account of medicinal chemistry of drugs affecting the adrenergic system. It provides the mechanisms of action of drugs and detail of structure-activity relationships of the adrenergic drugs to give the knowledge base for pharmacists. After the study of this chapter students will be able to:

• Comprehend the historical background of adrenergic neurochemistry and drugs acting on this system

• Explain adrenergic neurotransmitters and their functions

• Classify adrenergic receptors and their structures and binding

• Discuss direct and indirect acting sympathomimetic (adrenergic agonists) and sympatholytic (adrenergic antagonists) drugs

• Explain SAR for direct and indirect acting adrenergic receptor agonists and antagonists

• Delineate the clinical significance of these classes of drugs

• Identify the discovery process of these agents


Adrenergic agonists and antagonists, Adrenergic drugs, Clinical use of adrenergic drugs, Drug receptor interaction, Epinephrine and norepinephrine, Structure activity relationship, Sympathomimetic agents.


School of Pharmacy, University of Charleston, Charleston, WV, USA.