The ubiquitin (Ub)-proteasome system (UPS) targets various cellular proteins for degradation.
It has been found that defects in the UPS play a crucial role in the pathogenesis of
Alzheimer's disease (AD), as the existence of Ub immunoreactivity in AD-linked neuronal inclusions,
including neurofibrillary tangles, is observed in all types of AD cases. Current investigations
have shown that components of the UPS can be connected with the early stage of AD, which is
characterized by synaptic dysfunction, and to the late phases of the disease, marked by neurodegeneration.
Although the significance of UPS in the pathogenesis of AD has been emphasized, targeted
treatment at the main components of these pathways has a great perspective in advancing new
therapeutic interventions for AD. In this review, we emphasize the relationship between UPS and
AD pathology. We also represent the recent therapeutic advancements targeting UPS components