Purpose: Improving hypertension management is still one of the biggest challenges in public health
worldwide. Existing guidelines do not reach a consensus on the optimal Blood Pressure (BP) target. Therefore,
how to effectively manage hypertension based on individual characteristics of patients, combined with the pharmacological
and non-pharmacological approach, has become a problem to be urgently considered.
Methods: Reports published in PubMed that covered Pharmacological and Non-Pharmacological Approaches
in subjects taking hypertension management were reviewed by the group independently and collectively. Practical
recommendations for hypertension management were established by the panel.
Results: Pharmacological mechanism, action characteristics, and main adverse reactions varied across different
pharmacological agents, and patients with hypertension often require a combination of antihypertensive medications
to achieve the target BP range. Non-pharmacological treatment provides an additional effective method
for improving therapy adherence and long-term BP control, thus reducing the risk of cardiovascular diseases,
and slowing down the progression of the disease.
Conclusion: This review summarizes the available literature on the most convincing guideline principles, pharmacological
treatment, biotechnology interference, interventional surgical treatment, managing hypertension
with technical means of big data, Artificial Intelligence and Behavioral Intervention, as well as providing future
directions, for facilitating Current and Developing knowledge into clinical implementation.