Anti-Cancer Activity of Curcumin on Multiple Myeloma

Author(s): Hamed Mirzaei, Hossein Bagheri, Faezeh Ghasemi, Jaber M. Khoi, Mohammad H. Pourhanifeh, Yvan V. Heyden, Erfan Mortezapour, Ali Nikdasti, Philippe Jeandet, Haroon Khan, Amirhossein Sahebkar*

Journal Name: Anti-Cancer Agents in Medicinal Chemistry
(Formerly Current Medicinal Chemistry - Anti-Cancer Agents)

Volume 21 , Issue 5 , 2021

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Abstract:

Multiple Myeloma (MM) is the third most common and deadly hematological malignancy, which is characterized by a progressive monoclonal proliferation within the bone marrow. MM is cytogenetically heterogeneous with numerous genetic and epigenetic alterations, which lead to a wide spectrum of signaling pathways and cell cycle checkpoint aberrations. MM symptoms can be attributed to CRAB features (hyperCalcemia, Renal failure, Anemia, and Bone lesion), which profoundly affect both the Health-Related Quality of Life (HRQoL) and the life expectancy of patients. Despite all enhancement and improvement in therapeutic strategies, MM is almost incurable, and patients suffering from this disease eventually relapse. Curcumin is an active and non-toxic phenolic compound, isolated from the rhizome of Curcuma longa L. It has been widely studied and has a confirmed broad range of therapeutic properties, especially anti-cancer activity, and others, including anti-proliferation, anti-angiogenesis, antioxidant and anti-mutation activities. Curcumin induces apoptosis in cancerous cells and prevents Multidrug Resistance (MDR). Growing evidence concerning the therapeutic properties of curcumin caused a pharmacological impact on MM. It is confirmed that curcumin interferes with various signaling pathways and cell cycle checkpoints, and with oncogenes. In this paper, we summarized the anti- MM effects of curcumin.

Keywords: Curcumin, multiple myeloma, therapy, multidrug resistance, HRQoL, CRAB features.

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Article Details

VOLUME: 21
ISSUE: 5
Year: 2021
Published on: 24 February, 2021
Page: [575 - 586]
Pages: 12
DOI: 10.2174/1871520620666200918113625
Price: $65

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