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Current Stem Cell Research & Therapy

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ISSN (Print): 1574-888X
ISSN (Online): 2212-3946

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Review Article

Human Exfoliated Deciduous Teeth Stem Cells: Features and Therapeutic Effects on Neurogenerative and Hepatobiliary-pancreatic Diseases

Author(s): Nurul W.A. Wahab, Rhanye M. Guad, Vetriselvan Subramaniyan, Ismail M. Fareez, Ker W. Choy, Srinivasa R. Bonam, Chandrasekaran Selvaraju, Maw S. Sim, Subash C.B. Gopinath* and Yuan S. Wu*

Volume 16, Issue 5, 2021

Published on: 18 September, 2020

Page: [563 - 576] Pages: 14

DOI: 10.2174/1574888X15999200918105623

Price: $65

Abstract

Stem cells can multiply into more cells with similar types in an undifferentiated form and differentiate into other types of cells. The great success and key essence of stem cell technology is the isolation of high-quality Mesenchymal Stem Cells (MSCs) with high potency, either with multipotent or pluripotent property. In this line, Stem cells from Human Exfoliated Deciduous teeth (SHEDs) are highly proliferative stem cells from dental pulp and have multipoint differentiation capacity. These cells play a pivotal role in regenerative medicine, such as cell repair associated with neurodegenerative, hepatobiliary, and pancreatic diseases. In addition, stem cell therapy has been widely used to regulate immune response and repair of tissue lesions. This overview captured the differential biological characteristics, and the potential role of stem cell technology and paid special attention to human welfare SHEDs in eliminating the above-mentioned diseases. This review provides further insights into stem cell technology by expanding the therapeutic potential of SHEDs in tissue engineering and cell organ repairs.

Keywords: Totipotency, pluripotent, human exfoliated deciduous teeth, SHEDs, neurodegenerative disease, retinal degeneration, liver diseases, diabetes mellitus, organ transplantation.

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