Assessment of Biochemical Determinants in Multiple Sclerosis Patients Following the Oral Administration of β-D-Mannuronic Acid (M2000)

Author(s): Mohamad Reza Nikouei Moghaddam, Monireh Movahedi, Maryam Bananej, Soheil Najafi, Nahid Beladi Moghadam, Payam Saadat, Fariba Mokhtarian, Abbas Mirshafiey*

Journal Name: Current Drug Discovery Technologies

Volume 18 , Issue 5 , 2021

Article ID: e17092020186049
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Graphical Abstract:


Background: Multiple sclerosis is an autoimmune chronic inflammatory disease of the central nervous system that can lead to some serious disabilities. Despite using various immunomodulatory and anti-inflammatory drugs that have therapeutic effects, they cannot reduce its progression completely and have some unwanted side effects too. The immunomodulatory and anti-inflammatory effects of the β-D-Mannuronic acid (M2000) have been proven in several surveys, and the present research was designed to determine its toxicity and therapeutic effects in MS patients.

Methods: This study was performed on 15 MS patients who took 25 mg/kg/day the oral form of the β-D-Mannuronic acid for six months, and 15 healthy people as a control group. Serum levels of Urea, Creatinine, GGT, Vitamin D3, Uric acid, and Anti-Phospholipids were compared to evaluate the therapeutic and possible toxic effects of this drug after this period.

Results: Non- toxic effects through the study of urea, creatinine, GGT, and non-significant changes in uric acid and anti-Phospholipids levels, besides a significant rise in vitamin, D3 levels in the M2000 treated cases were found.

Conclusions: Our results suggested that β-D-Mannuronic acid is a safe drug and has no toxicity when administered orally and also has some therapeutic effects in MS patients.

Keywords: Mannuronic acid, M2000, multiple sclerosis, drug safety, toxicology, biochemical markers, NSAIDs.

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Article Details

Year: 2021
Published on: 17 September, 2020
Article ID: e17092020186049
Pages: 7
DOI: 10.2174/1570163817999200918104333
Price: $65

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